Aggressive multiple myeloma with brain involvement in a young patient

Area of Science:

• Hematology
• Oncology
• Neurology

Background:

• Multiple myeloma is a plasma cell neoplasm predominantly affecting older adults.
• Intracranial plasmacytomas are rare manifestations, especially in younger individuals.

Observation:

• A 28-year-old patient with plasma cell dyscrasia presented with multiple bone plasmacytomas.
• Bone marrow involvement was notably absent, a deviation from typical multiple myeloma presentation.
• The patient experienced cerebral involvement with complicating intratumorous hemorrhage.

Findings:

• This case highlights an unusual presentation of plasma cell dyscrasia in a young adult.
• The simultaneous occurrence of multiple bone plasmacytomas and intracranial involvement with hemorrhage is unique.
• The absence of bone marrow infiltration challenges conventional understanding of the disease's progression.

Implications:

• This case expands the known clinical spectrum of plasma cell dyscrasias.
• It underscores the importance of considering rare presentations in younger patients.
• Further research into atypical myeloma variants and their neurological complications is warranted.