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Updated: Sep 25, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Mixed chiral stationary phase containing modified resorcinarene and beta-cyclodextrin selectors bonded to a
Alexander Ruderisch1, Jens Pfeiffer, Volker Schurig
1Institute of Organic Chemistry, Auf der Morgenstelle 18, D-72076 Tübingen, Germany.
Abstract:
Both a resorcinarene with pendant L-valine diamide groups (used as hydrogen-bonding selector) and a permethylated beta-cyclodextrin (used as inclusion-type selector) were chemically bonded to poly(hydromethyl)dimethylsiloxane in a one-pot reaction via Pt-catalyzed alkene hydrosilylation. This novel mixed chiral stationary phase (mixCSP) named Chirasil-Calixval-Dex resembles a combination of the known chiral stationary phases (CSPs) Chirasil-Calixval and Chirasil-Dex and it was used successfully in enantioselective gas chromatography toward a unified enantioselective GC separation system. It is demonstrated that Chirasil-Calixval-Dex retains the individual enantioselectivites of the single components. Thus the enantiomers of apolar hydrocarbons as well as polar amino acid derivatives can be separated with the mixed CSP.
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