Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synchronization phenomena in nephron-nephron interaction.

Niels-Henrik Holstein-Rathlou1, Kay-Pong Yip, Olga V. Sosnovtseva

  • 1Department of Medical Physiology, Panum Institute, The University of Copenhagen, 2200 Copenhagen N, Denmark.

Chaos (Woodbury, N.Y.)
|June 5, 2003
PubMed
Summary

Kidney nephrons exhibit synchronized pressure oscillations. This study reveals in-phase and antiphase synchronization in normal rats and chaotic synchronization in hypertensive rats, modeled mathematically.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA-625-3p Increases Chemosensitivity in Ovarian Cancer Cells Through Decreasing SSX2IP-Mediated Cisplatin Export in Extracellular Vesicles.

Cancers·2026
Same author

From blood flow to organ function: The physiology of autoregulatory dynamics.

Experimental physiology·2025
Same author

Toward a full-scale model of renal hemodynamics using a reconstructed vascular tree.

American journal of physiology. Renal physiology·2025
Same author

Response of the Nephron Arterial Network and Its Interactions to Acute Hypertension: A Simulation.

Function (Oxford, England)·2024
Same author

The renal vasodilatation from β-adrenergic activation in vivo in rats is not driven by K<sub>V</sub>7 and BK<sub>Ca</sub> channels.

Experimental physiology·2024
Same author

Cardiovascular autonomic nervous function in children conceived by assisted reproductive technology with frozen or fresh embryo transfer.

American journal of physiology. Heart and circulatory physiology·2023

Area of Science:

  • Physiology
  • Biophysics
  • Nephrology

Background:

  • Kidney functional units, nephrons, exhibit tubular pressure oscillations.
  • Synchronization patterns between adjacent nephrons are not fully understood.
  • Hypertension can alter normal nephron pressure dynamics.

Purpose of the Study:

  • To analyze experimental data on tubular pressure oscillations in rat kidneys.
  • To investigate different types of synchronization between neighboring nephrons.
  • To develop and validate a mathematical model for nephron synchronization.

Main Methods:

  • Analysis of experimental data on tubular pressure and flow variations in rat kidneys.
  • Development of a mathematical model incorporating hemodynamic and vascular coupling between adjacent nephrons.

Related Experiment Videos

  • Simulation of pressure and flow regulation in a pair of nephrons.

    • Main Results:

    • In-phase and antiphase synchronization observed in normal blood pressure rats.
    • Chaotic phase and frequency synchronization identified in spontaneously hypertensive rats.
    • The mathematical model successfully reproduced experimentally observed synchronization patterns.

    Conclusions:

    • Kidney nephron synchronization is influenced by blood pressure regulation.
    • Mathematical modeling provides insights into complex renal functional unit interactions.
    • Understanding synchronization dynamics is crucial for renal physiology and pathology.