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Related Experiment Videos

Relationship between optic nerve head microcirculation and visual field loss in glaucoma.

Kiyoshi Yaoeda1, Motohiro Shirakashi, Atsushi Fukushima

  • 1Department of Ophthalmology, Faculty of Medicine, Niigata University, Niigata City, Japan. arasan@med.niigata-u.ac.jp

Acta Ophthalmologica Scandinavica
|June 5, 2003
PubMed
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Optic nerve head blood flow, measured by square blur rate (SBR), is linked to visual field loss in normal tension glaucoma (NTG) but not primary open-angle glaucoma (POAG). This suggests circulation changes may impact NTG progression more significantly.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Neuro-ophthalmology

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Optic nerve head (ONH) blood flow is crucial for retinal ganglion cell survival.
  • Understanding the relationship between ONH circulation and visual field loss is vital for glaucoma management.

Purpose of the Study:

  • To investigate the association between optic nerve head blood flow velocity and visual field defects.
  • To compare these relationships in patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG).

Main Methods:

  • Laser speckle flowgraphy was used to measure optic nerve head blood flow velocity via the square blur rate (SBR).
  • 44 eyes of 44 NTG patients and 44 eyes of 44 POAG patients were included.

Related Experiment Videos

  • Linear regression analysis correlated SBR with Humphrey visual field indices.

    • Main Results:

    • In NTG, SBR at the superior/inferior temporal neuroretinal rim positively correlated with mean deviation (MD) and total deviation.
    • No significant correlation between SBR and visual field indices was found in the POAG group.
    • Statistical differences in SBR-MD correlations between NTG and POAG groups were not significant.

    Conclusions:

    • Optic nerve head circulatory changes may contribute to visual field damage in NTG.
    • Circulation appears less involved in visual field damage progression in POAG.
    • Further research into ONH hemodynamics in different glaucoma subtypes is warranted.