Related Experiment Video
Updated: Aug 10, 2026
04:37
A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
Onychomycosis due to Onychocola canadensis
N B O'Donoghue1, M K Moore, D Creamer
1Department of Dermatology, King's College Hospital, and Department of Mycology, St John's Institute of Dermatology, Kings College, London, UK. nualadonoghue@doctors.org.uk
Clinical and Experimental Dermatology
|June 5, 2003
Summary
Onychocola canadensis, a rare mould, can cause nail infections (onychomycosis). This case highlights a patient resistant to standard terbinafine treatment, indicating potential challenges in managing this uncommon fungal infection.
Area of Science:
- Medical Mycology
- Dermatology
Background:
- Onychocola canadensis is an uncommon nondermatophyte mould.
- It is known to cause onychomycosis and rarely tinea manuum, primarily affecting elderly individuals in temperate regions.
Observation:
- A case of onychomycosis caused by Onychocola canadensis is presented.
- The affected patient was an elderly individual.
Findings:
- The patient's onychomycosis did not respond to a 12-week course of terbinafine 250 mg once daily.
- This suggests potential terbinafine resistance in Onychocola canadensis-induced onychomycosis.
Implications:
- This case underscores the need for considering alternative or combination therapies for Onychocola canadensis onychomycosis.
- Further research into treatment strategies for this uncommon fungal infection is warranted.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:28Fungal Phylum Microsporidia
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...