Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal 5-HT1D receptor function in cluster headache: a neuroendocrine study with sumatriptan.

L Pinessi1, I Rainero, W Valfrè

  • 1Neurology III, Headache Centre, Department of Neuroscience, Division of Endocrinology, Department of Internal Medicine and Division of Medicine, Department of Internal Medicine, University of Turin, Turin, Italy. lorenzo.pinessi@unito.it

Cephalalgia : an International Journal of Headache
|June 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetic retinopathy screening telemedicine-based compared with standard of care : an economic analysis in a pilot experience of Italian healthcare.

Acta diabetologica·2025
Same author

Calcium/phosphate ratio: an additional tool for the clinical management of asymptomatic primary hyperparathyroidism?

Journal of endocrinological investigation·2023
Same author

Endocrinologists at work: management of hyponatremia in clinical practice.

Journal of endocrinological investigation·2023
Same author

Impact of allogeneic stem cell transplantation on thyroid function.

Journal of endocrinological investigation·2023
Same author

Benefits of dual-release hydrocortisone treatment on central adiposity and health-related quality of life in secondary adrenal insufficiency.

Journal of endocrinological investigation·2022
Same author

A mathematical model for the evaluation of iron transport across the blood-cerebrospinal fluid barrier in neurodegenerative diseases.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2020

This study found altered 5-HT(1D) receptor function in episodic cluster headache patients. Sumatriptan, a 5-HT(1B/1D) agonist, showed blunted effects on growth hormone and reduced responses in prolactin and ACTH.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Endocrinology

Background:

  • Episodic cluster headache is a debilitating neurological disorder.
  • Serotonergic systems, particularly 5-HT(1D) receptors, play a role in headache pathophysiology.
  • Sumatriptan is a selective 5-HT(1B/1D) agonist used to probe serotonergic function.

Purpose of the Study:

  • To assess the sensitivity of 5-HT(1D) receptors in patients with episodic cluster headache.
  • To investigate in vivo serotonergic system function using sumatriptan as a pharmacological probe.

Main Methods:

  • Subcutaneous sumatriptan and placebo were administered to 20 patients with episodic cluster headache (10 active, 10 remission) and 12 controls.
  • Sumatriptan-induced changes in growth hormone, prolactin, adrenocorticotropic hormone (ACTH), and cortisol were measured.

Related Experiment Videos

Main Results:

  • The sumatriptan-induced increase in growth hormone was significantly blunted in patients with active cluster headache (P < 0.05).
  • Prolactin and ACTH responses to sumatriptan were significantly reduced in patients with cluster headache, both in active and remission periods (P < 0.05).

Conclusions:

  • Cerebral serotonergic functions mediated by 5-HT(1D) receptors appear to be altered in patients with episodic cluster headache.
  • These findings suggest a potential role for 5-HT(1D) receptor dysfunction in the pathophysiology of cluster headaches.