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Advances in the management of malignant mesothelioma
Mazen Y Khalil1, Marissa Mapa, Hyung Ju C Shin
1Division of Hematology and Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Abstract:
Malignant mesotheliomas are very aggressive tumors that originate from mesothelial cells, which form the serosal lining of the pleura, pericardial, and peritoneal cavities. Finding effective chemotherapeutic treatment for malignant mesothelioma is a challenge. There is no standard treatment because this tumor is relatively resistant to therapy. A resurgence of interest has been expressed in novel therapies and conventional treatments used in different ways. Several treatment modalities have been studied, including chemotherapy, radiotherapy, surgery, and immunotherapy. Chemotherapy can be administered systemically or directly into the pleura. This review presents the results of the most recent trials and highlights the most promising advances in the battle against this aggressive disease.
Insights
Malignant mesothelioma treatment remains challenging due to tumor resistance. This review highlights recent trials and promising advances in chemotherapy and other therapies for this aggressive cancer.
Area of Science:
- Oncology
- Cancer Research
Background:
- Malignant mesotheliomas are aggressive tumors arising from mesothelial cells lining body cavities.
- Effective chemotherapeutic treatment for malignant mesothelioma is difficult due to inherent tumor resistance.
- There is no established standard treatment, necessitating exploration of novel therapeutic strategies.
Purpose of the Study:
- To review recent clinical trials and therapeutic advances for malignant mesothelioma.
- To highlight promising novel therapies and repurposed conventional treatments.
- To provide an overview of current treatment modalities including chemotherapy, radiotherapy, surgery, and immunotherapy.
Main Methods:
- Systematic review of recent clinical trials and research publications.
- Analysis of treatment outcomes for various therapeutic approaches.
- Focus on chemotherapy administered systemically and intrapleurally.
Main Results:
- Malignant mesothelioma exhibits significant resistance to conventional therapies.
- Chemotherapy, including systemic and intrapleural administration, shows variable efficacy.
- Ongoing research explores novel agents and combination therapies.
Conclusions:
- Developing effective treatments for malignant mesothelioma remains a critical challenge.
- Recent trials offer insights into promising therapeutic avenues.
- A multimodal approach integrating chemotherapy, radiotherapy, surgery, and immunotherapy may be beneficial.