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Updated: Jul 23, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
[Heterogenicity of Gorham-Stout syndrome: association with lymphatic and venous malformations]
I Somoza Argibay1, M Díaz González, L Martínez Martínez
1Unidad de Cirugía Plástica Infantil. Servicio de Cirugía Pediátrica. Hospital Materno Infantil La Paz. Madrid. España. isomoza@canalejo.org
Introduction:
Gorham-Stout syndrome is a rare disorder of unknown etiology characterized by osteolysis and microscopic proliferation of abnormal vessels. We report two cases of this syndrome associated with lymphatic and venous malformations.
Case Reports:
The first case is a 5-year-old boy with disseminated lymphangiomatosis of poor prognosis, with significant pleural involvement and osteolytic lesions. The second case is a 5-year-old girl with a diagnosis of Klippel-Trenaunay syndrome with significant skeletal involvement of the lower extremities and secondary pathological fracture.
Conclusions:
Gorham-Stout syndrome may occasionally be associated with various lymphatic and venous malformations. Osteolysis and bone resorption may be induced by lymphatic bone involvement.
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