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Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues
Siham El Fangour1, Laurence Balas, Jean-Claude Rossi
1UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 5, Montpellier Cedex, France. balas@pharma.univ-montpl.fr
Bioorganic & Medicinal Chemistry Letters
|June 5, 2003
Abstract:
Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.