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A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide
Sangtae Oh1, In Howa Jeong, Woon Seob Shin
1Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
Abstract:
Coronarin A 1, epi-coronarin A 2 and some synthetic intermediates 14a and 14b synthesized from sclareolide exhibit good growth inhibition activities on HUVEC proliferation. In particular, coronarin A 1 and epi-coronarin A 2 effectively suppressed the growth factor induced tube formation of HUVEC at the concentration of 10 micro g/mL.
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