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Urea small molecule agonists on mouse melanocortin receptors
Christine G Joseph1, Rayna M Bauzo, Zhimin Xiang
1Department of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
Bioorganic & Medicinal Chemistry Letters
|June 5, 2003
Abstract:
A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.