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Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

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Blood transfusion safety: correct patient identification is essential.

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Related Experiment Video

Updated: Jul 15, 2026

Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Haemophilias A and B.

Paula H B Bolton-Maggs1, K John Pasi

  • 1Department of Haematology, Royal Liverpool Children's Hospital, Liverpool, UK. p.h.boltonmaggs@liv.ac.uk <p.h.boltonmaggs@liv.ac.uk>

Lancet (London, England)
|June 5, 2003
PubMed
Summary

Haemophilia, inherited bleeding disorders, now offers normal life expectancy due to advanced treatments. Future gene therapy holds promise, but global access remains a challenge for this widespread condition.

Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Haemophilias are inherited coagulation factor deficiencies, including Factor VIII (A) and Factor IX (B).
  • Von Willebrand's disease is more common, and rare defects can affect any coagulation factor.
  • Historically, haemophilia led to premature death, but advancements have improved life expectancy.

Purpose of the Study:

  • To review the current understanding of haemophilias and their management.
  • To discuss the impact of treatment advancements and ongoing challenges.
  • To explore future therapeutic possibilities, including gene therapy.

Main Methods:

  • Literature review of inherited bleeding disorders.
  • Analysis of historical and current treatment outcomes for haemophilia.

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Last Updated: Jul 15, 2026

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  • Discussion of complications and future research directions.

    • Main Results:

    • Significant improvements in life expectancy for individuals with haemophilia.
    • Development of effective treatments, though complications like inhibitors and transfusion-transmitted infections persist.
    • Gene therapy represents a promising future treatment avenue.

    Conclusions:

    • Modern treatments enable a normal life expectancy for many with haemophilia.
    • Challenges include treatment-related complications and equitable global access to care.
    • Gene therapy offers potential for a definitive cure, but resource limitations must be addressed.