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Selective pressures on genomes in molecular evolution.

Charles Ofria1, Christoph Adami, Travis C Collier

  • 1Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA. ofria@msu.edu

Journal of Theoretical Biology
|June 5, 2003
PubMed
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Evolution is viewed as information transmission. Three selective pressures—compression, transmission, and neutrality selection—shape genome length and information encoding, impacting evolvability. These pressures were observed in digital organisms.

Area of Science:

  • Evolutionary biology
  • Information theory
  • Genomics

Background:

  • Macromolecular evolution can be framed as an information transmission process.
  • Shannon information theory provides tools to analyze this process.
  • Understanding selective pressures is key to explaining evolutionary trajectories.

Purpose of the Study:

  • To apply information theory to macromolecular evolution.
  • To identify and define independent, competing selective pressures.
  • To investigate the implications of these pressures on evolvability.

Main Methods:

  • Utilized Shannon information theory to model evolution.
  • Defined and analyzed three selective pressures: compression, transmission, and neutrality selection.

Related Experiment Videos

  • Conducted experiments with digital organisms to demonstrate these pressures.

    • Main Results:

    • Identified compression and transmission selection influencing genome length.
    • Demonstrated neutrality selection maximizing neutral mutations in noisy channels.
    • Observed these selective pressures in digital organism evolution experiments.

    Conclusions:

    • Information theory offers a novel framework for understanding macromolecular evolution.
    • Neutrality selection plays a crucial role in the evolution of evolvability.
    • The interplay of these pressures drives evolutionary adaptation and diversification.