Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Metalloproteinases and angiogenesis].

E E Gabison1, T Hoang-Xuan, A Mauviel

  • 1Unité 532 Inserm, Institut de recherche sur la peau, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Pathologie-Biologie
|June 5, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe corneal manifestations of graft-versus-host disease: Experience of a tertiary referral center.

The ocular surface·2024
Same author

Outpatient vs. inpatient Descemet's membrane endothelial keratoplasty: Changing practice patterns in a COVID-19 environment.

Journal francais d'ophtalmologie·2022
Same author

Sclerostin Deficiency Promotes Reparative Dentinogenesis.

Journal of dental research·2017
Same author

Deletion of extracellular matrix metalloproteinase inducer/CD147 induces altered cardiac extracellular matrix remodeling in aging mice.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2015
Same author

Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours.

International journal of andrology·2012
Same author

Integrating developmental signals: a Hippo in the (path)way.

Oncogene·2011

Metalloproteinases (MMPs) regulate angiogenesis by breaking down tissues and influencing cell behavior. These enzymes are key to blood vessel formation, impacting cell growth and survival.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Context:

  • Angiogenesis is crucial for development and disease.
  • Metalloproteinases (MMPs) play multifaceted roles in biological processes.
  • Endothelial cells are central to blood vessel formation.

Purpose:

  • To elucidate the regulatory roles of MMPs in angiogenesis.
  • To understand how MMPs influence endothelial cell functions during blood vessel formation.

Summary:

  • Metalloproteinases (MMPs) are critical regulators of angiogenesis.
  • They facilitate extracellular matrix degradation, growth factor mobilization, and generate bioactive fragments.
  • MMPs impact endothelial cell migration, invasion, proliferation, and survival by modulating angiogenic balance.

Related Experiment Videos

Impact:

  • Provides insights into the molecular mechanisms of angiogenesis.
  • Highlights MMPs as potential therapeutic targets in angiogenesis-related diseases.
  • Enhances understanding of endothelial cell biology and extracellular matrix interactions.