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Related Experiment Videos

Compulsive behavior in the 5-HT2C receptor knockout mouse.

Jennifer M Chou-Green1, Todd D Holscher, Mary F Dallman

  • 1Department of Physiology, University of California-San Francisco, 513 Parnassus Avenue, Box 0444, San Francisco, CA 94143, USA.

Physiology & Behavior
|June 5, 2003
PubMed
Summary

Mice lacking serotonin 5-HT(2C) receptors exhibit compulsive-like behaviors, including increased clay chewing and altered screen chewing patterns. This finding supports the role of serotonin in obsessive-compulsive disorder (OCD) and validates a new animal model.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Serotonergic pharmacotherapy is effective for obsessive-compulsive disorder (OCD), suggesting serotonin's (5-HT) involvement in its etiology or treatment.
  • Clinical evidence implicates 5-HT(2C) receptors in OCD, but their precise function remains unconfirmed.

Purpose of the Study:

  • To investigate the potential role of 5-HT(2C) receptors in compulsive behavior.
  • To characterize behaviors in mice lacking functional 5-HT(2C) receptors (KO mice) to determine if they exhibit a compulsive-like syndrome.

Main Methods:

  • Assessment of compulsive-like behavior in male 5-HT(2C) receptor knockout (KO) and wildtype (WT) mice.
  • Measurement of non-nutritive clay chewing, plastic-mesh screen chewing patterns, and head dipping frequency.

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Main Results:

  • 5-HT(2C) receptor KO mice demonstrated significantly increased chewing of non-nutritive clay compared to WT mice.
  • KO mice exhibited a distinct "neat" chewing pattern on plastic screens.
  • Reduced habituation of head dipping activity was observed in KO mice relative to WT controls.

Conclusions:

  • The 5-HT(2C) receptor null mutant mouse presents a promising animal model for studying compulsive behavior.
  • This model facilitates further exploration into the role of serotonin (5-HT) in the pathophysiology of OCD.