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DNA damage in brain cells of mice treated with an oxidized form of apomorphine
Jaqueline Nascimento Picada1, Debora G Flores, Cláudio G Zettler
1GENOTOX-Genotoxicity Laboratory, Center for Biotechnology, and Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, 91501-970, RS, Porto Alegre, Brazil.
Abstract:
We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.
