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Developmental noise, ageing and cancer.
Armando Aranda-Anzaldo1, Myrna A R Dent
1Laboratorio de Biología Molecular, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. México, Mexico. aaa@coatepec.uaemex.mx
Mechanisms of Ageing and Development
|June 5, 2003
Summary
Cancer may be an intrinsic developmental process, not acquired. Early life's random "developmental noise" creates varied cancer susceptibilities, with tumor suppressors like p53 acting as buffers against these early effects.
Area of Science:
- Developmental Biology
- Cancer Biology
- Gerontology
Background:
- Developmental processes are susceptible to random variations known as developmental noise.
- Early developmental noise can lead to long-term consequences in system organization and function.
Purpose of the Study:
- To present evidence that cancer is an intrinsic developmental process influenced by early random factors.
- To explore the role of developmental noise and buffering mechanisms in cancer and aging.
Main Methods:
- Review and discussion of existing evidence on developmental noise and cancer.
- Analysis of the proposed role of tumor suppressor functions (e.g., p53) as developmental buffers.
- Conceptual framework linking morphological disorder, aging, and cancer.
Main Results:
- Cancer may arise intrinsically from developmental noise, creating varied susceptibility types.
- Tumor suppressor functions, like p53, may have evolved to buffer against developmental instability.
- Morphological disorder, a form of aging, is proposed as a common theme in cancer.
Conclusions:
- Cancer and aging share common links through the exhaustion of developmental constraints and buffering mechanisms.
- Cancer can be viewed as a radical form of aging, exhibiting intrinsicality, progressiveness, and deleteriousness.