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Related Experiment Videos

Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification.

Naoki Hashimoto1, Tohru Takeuchi, Ryoko Ishihara

  • 1Department of Psychiatry, Imaise Branch, Ichinomiya Municipal Hospital, 30 Gochuchawara Miyaushiro Imaise, Ichinomiya, 491-0057 Aichi, Japan. nhashimoto-psy@umin.ac.jp

Acta Neuropathologica
|June 5, 2003
PubMed
Summary

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Glial fibrillary tangles (GFT) in diffuse neurofibrillary tangles with calcification (DNTC) were identified in astrocytes and oligodendrocytes. These GFT, particularly in temporal and limbic lobes, show distinct tau and ubiquitin immunoreactivity.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Cell Biology

Background:

  • Diffuse neurofibrillary tangles with calcification (DNTC) is a neurodegenerative disease characterized by abnormal protein aggregation.
  • The cellular origins and specific pathological markers of glial fibrillary tangles (GFT) within DNTC require detailed investigation.

Purpose of the Study:

  • To investigate the occurrence and distribution of glial fibrillary tangles (GFT) in diffuse neurofibrillary tangles with calcification (DNTC).
  • To classify GFT morphologically and examine their immunoreactivity for tau and ubiquitin.
  • To identify the glial cell types associated with GFT.

Main Methods:

  • Gallyas-Braak (GB) staining was employed to visualize GFT and related structures.
  • Immunohistochemistry was used to detect tau and ubiquitin.

Related Experiment Videos

  • Glial fibrillary acidic protein (GFAP) and transferrin immunostaining identified astrocytes and oligodendrocytes, respectively.

    • Main Results:

    • Three types of GFT were identified in astrocytes and oligodendrocytes, predominantly in the temporal and limbic lobes.
    • Coiled bodies in oligodendrocytes were positive for tau and ubiquitin.
    • Thorn-shaped astrocytes (tau-positive, ubiquitin-negative) and tuft-shaped astrocytes (tau- and ubiquitin-positive) were observed in specific brain regions.

    Conclusions:

    • GFT are present in both astrocytes and oligodendrocytes in DNTC, with distinct morphological and biochemical characteristics.
    • The distribution of GFT aligns with the most affected brain regions in DNTC.
    • GFT represent a significant pathological feature within glial cells in DNTC, distinct from extracellular neurofibrillary tangles.