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Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis
Ilias G Kirkinezos1, Dayami Hernandez, Walter G Bradley
1Department of Cell Biology, University of Miami School of Medicine, Miami, FL 33136, USA.
Annals of Neurology
|June 5, 2003
Abstract:
We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.