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Gender, ethnicity, and genes in cardiovascular disease. Part 2: implications for pharmacotherapy
Benjamin M Schaefer1, Vincent Caracciolo, William H Frishman
1Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
Heart Disease (Hagerstown, Md.)
|June 5, 2003
Abstract:
Women are underrepresented in clinical trials. Lower doses of beta-blockers are required for Southeast Asians. ACE and ARB's are teratogenic in the second trimester. Torsades de Pointes is more common in women related to a longer QT-interval. Lower dose OCPs decrease the risk of MI, stroke and thrombosis. HRTs are not effective for CAD prevention.