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Updated: Sep 25, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
[Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer]
Li-qun Zhou1, Xue-zhen Yang, Li Zeng
1Institute of Urology, First Hospital, Peking University, Beijing 100034, China.
Objective:
To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.
Methods:
Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.
Results:
Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.
Conclusion:
Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.
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