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Related Experiment Videos

[Cross-reactivity between fruit and vegetables].

M Fernández Rivas1

  • 1Fundación Hospital Alcorcón. Unidad de Alergia. Alcorcón. Madrid. Spain.

Allergologia Et Immunopathologia
|June 5, 2003
PubMed
Summary
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Vegetable allergies in individuals over 5 are common, often linked to pollen allergies due to cross-reactive panallergens like Bet v 1, profilins, and lipid transfer proteins (LTPs). Understanding these panallergens is key to diagnosing and managing complex food allergies.

Area of Science:

  • Immunology and Allergy
  • Food Science
  • Biochemistry

Context:

  • Vegetable foods are a primary cause of food allergies in individuals over five years old.
  • Multiple sensitizations to various vegetable products are frequent in allergic patients, often co-occurring with pollen allergies.
  • Cross-reactivity, driven by IgE antibodies to panallergens, underlies these associations.

Purpose:

  • To explore the role of panallergens in vegetable food allergies and their association with pollen allergies.
  • To detail the characteristics and clinical relevance of major panallergen groups: Bet v 1-homologous allergens, profilins, and lipid transfer proteins (LTPs).
  • To explain the prevalence and clinical impact of these allergies, particularly in Mediterranean regions.

Summary:

  • Panallergens, conserved proteins across the plant kingdom, trigger cross-reactivity. Bet v 1-homologous allergens (PR-10) are linked to birch pollen allergy and oral allergy syndrome.

Related Experiment Videos

  • Profilins (14 kDa) are highly conserved and cross-reactive, but their correlation with clinical food allergy symptoms is uncertain.
  • Lipid transfer proteins (LTPs, 9 kDa) are heat-stable, common in Mediterranean allergies (e.g., Rosaceae fruits), and associated with severe systemic reactions like anaphylaxis.

    • Impact:

    • Identifies key panallergens responsible for widespread vegetable and pollen allergies.
    • Provides insights into the mechanisms of cross-reactivity, aiding in diagnosis and management strategies.
    • Highlights the significance of LTPs in severe allergic reactions in specific geographic areas.