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Aerobic capacity and peripheral skeletal muscle function in coronary artery disease male patients

M Gayda1, A Merzouk, D Choquet

  • 1Laboratoire de recherche EA 3300 APS et Conduites Motrices: Adaptations et Réadaptations, Faculté des Sciences du Sport, Université de Picardie Jules Verne, 80025 Amiens Cedex 1, France.

International Journal of Sports Medicine
|June 5, 2003
PubMed

Insights

Coronary artery disease (CAD) patients exhibit reduced aerobic capacity and impaired skeletal muscle endurance compared to healthy individuals. This study found lower static endurance time in CAD patients, indicating a decline in muscle function.

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Skeletal Muscle Physiology

Background:

  • Coronary artery disease (CAD) is associated with reduced physical capacity.
  • The impact of CAD on peripheral skeletal muscle function requires further elucidation.

Purpose of the Study:

  • To investigate whether diminished aerobic capacity in male CAD patients is linked to impaired skeletal muscle function.
  • Compare skeletal muscle function in CAD patients versus healthy controls.

Main Methods:

  • Maximal laboratory exercise testing and isokinetic peripheral skeletal muscle function assessment.
  • Measured cardiorespiratory and mechanical parameters at ventilatory threshold and maximal effort.
  • Assessed quadriceps maximal voluntary isometric force (MVIF) and static endurance time (SET).

Main Results:

  • CAD patients demonstrated significantly lower aerobic capacity (maximal VO(2) uptake, ventilation, heart rate, power) at maximal effort and ventilatory threshold.
  • No significant difference in maximal voluntary isometric force (MVIF) between groups.
  • CAD patients exhibited a significantly lower static endurance time (SET) compared to controls.

Conclusions:

  • Male CAD patients possess diminished aerobic capacity compared to healthy subjects.
  • Skeletal muscle function is impaired in CAD patients, specifically in terms of endurance.
  • Reduced aerobic capacity in CAD is accompanied by impaired skeletal muscle endurance.

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