Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleepiness in Parkinson's disease: a controlled study.

Matthew A Brodsky1, James Godbold, Tom Roth

  • 1Mount Sinai School of Medicine, New York, New York 10029, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|June 5, 2003
PubMed
Summary

Parkinson's disease patients experience more sleepiness and driving sleep episodes, linked to dopaminergic medication. Early identification and treatment of excessive daytime sleepiness are crucial for PD drivers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inconsistent use of evolutionary frameworks in accounts of romantic relationships.

The Behavioral and brain sciences·2026
Same author

Enclosures with flexible structures stimulate species-typical locomotion, but not locomotion quantity, in zoo-housed Bornean orangutans (<i>Pongo pygmaeus</i>).

Animal welfare (South Mimms, England)·2026
Same author

LRRK2-targeting antisense oligonucleotide in Parkinson's disease: a phase 1 randomized controlled trial.

Nature medicine·2026
Same author

A double-blind, controlled trial of circadian effective light therapy in patients with Parkinson's disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

CVN424, a GPR6 inverse agonist, for Parkinson's disease and motor fluctuations: a double-blind, randomized, phase 2 trial.

EClinicalMedicine·2024
Same author

Continuous Levodopa Delivery with an Intraoral Micropump System: An Open-Label Pharmacokinetics and Clinical Study.

Movement disorders : official journal of the Movement Disorder Society·2024

Area of Science:

  • Neurology
  • Sleep Medicine
  • Movement Disorders

Background:

  • Parkinson's disease (PD) is associated with sleep disturbances.
  • Sudden, irresistible sleep episodes while driving (sleep attacks) are a concern in PD patients.
  • Excessive daytime sleepiness (EDS) is a common symptom in PD, potentially exacerbated by dopaminergic medications.

Purpose of the Study:

  • To assess the frequency of EDS and its relationship with sleep episodes while driving (SE) in Parkinson's disease patients.
  • To identify predictors of SE in PD patients.

Main Methods:

  • A questionnaire-based study evaluating 101 consecutive PD patients and 100 age-matched controls.
  • Inclusion of subjective sleepiness estimates, the Epworth Sleepiness Scale (ESS), and data on disease severity and dopaminergic medication.

Related Experiment Videos

  • Statistical analysis including logistic regression to determine predictors of SE.

    • Main Results:

    • 76% of PD patients reported EDS versus 47% of controls (P < 0.05).
    • PD patients had significantly higher mean ESS scores (9.1 vs. 5.7; P < 0.001) and a higher prevalence of scores >=10 and >=15.
    • 20.8% of PD drivers experienced SE compared to 6% of control drivers (P < 0.05).
    • Higher daily levodopa (L-dopa) equivalent dose (P < 0.05) and higher ESS scores (P < 0.05) were associated with SE in PD drivers.
    • Logistic regression identified ESS and L-dopa dose as predictors of SE.

    Conclusions:

    • Sleep episodes while driving in Parkinson's disease are significantly associated with excessive daytime sleepiness and dopaminergic medication load.
    • Physicians should counsel PD patients about the risks of EDS and SE while driving.
    • Management strategies should address EDS and medication adjustments in PD patients.