Acute coronary syndrome and late stent failure in a patient with Behçet's syndrome

Area of Science:

• Cardiology
• Rheumatology
• Vascular Medicine

Background:

• Behçet's syndrome is a rare multisystem inflammatory disease.
• Vascular involvement is a significant complication of Behçet's syndrome.
• Coronary artery disease is an uncommon but serious manifestation.

Observation:

• This case report details a patient with Behçet's syndrome who experienced acute coronary syndrome.
• The patient also developed a complication following percutaneous coronary intervention (PCI).
• The complication involved late in-stent reocclusion.

Findings:

• An active phase of Behçet's syndrome may predispose to cardiovascular events.
• Increased oxidative stress and reduced nitric oxide availability are potential mechanisms.
• These mechanisms could explain both early myocardial infarction and late in-stent reocclusion post-PCI.

Implications:

• Behçet's syndrome requires careful cardiovascular monitoring.
• Understanding the pathophysiology may guide treatment strategies for cardiovascular complications.
• Management of these complications in Behçet's syndrome patients can be challenging.