[Sodium release from tissue paracellular space under the influence of angiotensin II]

Angiotensin II added in vitro in concentration 3-10(-10) M increased the sodium release from the aorta wall, myocardium, and skin in the rat. The action persisted at 2 degrees C and in presence of monoiodacetate. Sodium loading increased the sensitivity of aorta to the action of the angiotensin. The angiotensin-induced sodium release seems to be a step towards the myotropic action of the peptide.