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Related Experiment Videos

Embedding a native state into a random heteropolymer model: the dynamic approach.

Z Konkoli1, J Hertz

  • 1Department of Applied Physics, Chalmers University of Technology and Göteborg University, SE 412 96 Göteborg, Sweden.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 6, 2003
PubMed
Summary

This study explores a heteropolymer model, revealing a spin-glass phase at high selection temperatures and an ordered phase at low temperatures. Folding is rapid between these transitions, but systems can become trapped in non-native states.

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Random heteropolymer dynamics.

Physical review. E, Statistical, nonlinear, and soft matter physics·2001

Area of Science:

  • Statistical mechanics
  • Biophysics
  • Polymer physics

Background:

  • Heteropolymers are complex molecules with diverse applications.
  • Understanding their folding dynamics is crucial for molecular biology and materials science.
  • Previous studies focused on random heteropolymers without selection pressure.

Purpose of the Study:

  • To investigate the phase behavior of a heteropolymer model under varying selection temperatures.
  • To analyze the influence of a "selection temperature" (T0) on polymer folding and dynamics.
  • To compare the model's behavior with that of a standard random heteropolymer.

Main Methods:

  • Utilized a supersymmetric formulation of Langevin dynamics.
  • Employed a Gaussian variational approach for phase analysis.

Related Experiment Videos

  • Constructed a modified ensemble with a tunable selection temperature (T0).

    • Main Results:

    • Identified a dynamical spin-glass phase at high T0, similar to random heteropolymers, below temperature T(g).
    • Discovered an ordered phase at low T0, with non-zero overlap to the native state, below temperature T(n).
    • Observed that the random-globule phase persists below T(n) down to T(g), indicating potential trapping in non-native states.

    Conclusions:

    • Folding is rapid for temperatures between T(g) and T(n).
    • Below T(g), the system can become trapped in conformations unrelated to the native state.
    • At lower temperatures, the ordered phase can exhibit a dynamical glass transition, leading to complex substates.