Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between proteins bound to biomembranes.

A R Evans1, M S Turner, P Sens

  • 1Department of Physics, University of Warwick, Coventry CV4 7AL, United Kingdom.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computed tomography can assess aortic valve stenosis by planimetry, enhances the continuity equation, reveals an anatomical ratio that mimics the dimensionless velocity index and demonstrates limitations in the use of calcification in stenosis severity assessment.

Clinical radiology·2026
Same author

The design and use of a simple device for the MRI assessment of changes in cardiovascular function by lower-body negative-pressure-simulated reduction of central blood volume.

Clinical radiology·2021
Same author

RETRACTION: The roles of the cation transporters CHX21 and CHX23 in the development of Arabidopsis thaliana.

Journal of experimental botany·2021
Same author

Inferring diet, feeding behaviour and causes of mortality from prey-induced injuries in a New Zealand fur seal.

Diseases of aquatic organisms·2020
Same author

Model of Cell Crawling Controlled by Mechanosensitive Adhesion.

Physical review letters·2017
Same author

Fluctuations of a membrane nanotube revealed by high-resolution force measurements.

Soft matter·2016
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

This study models protein interactions with cell membranes, finding repulsive forces between circular inclusions on tensioned membranes, unlike attraction on tensionless ones. This physical model explains membrane-shaping events like caveolae budding.

Area of Science:

  • Biophysics
  • Soft Matter Physics
  • Cell Biology

Background:

  • Cell membranes are dynamic structures influenced by proteins.
  • Proteins interacting with membranes can exert forces, affecting membrane morphology.
  • Understanding these forces is crucial for cellular processes like vesicle formation.

Purpose of the Study:

  • To develop a physical model for interactions between membrane-bound inclusions and fluid membranes.
  • To investigate the role of membrane tension and bending rigidity on these interactions.
  • To explain biological phenomena such as caveolae formation and coat striations.

Main Methods:

  • Derivation of an exact analytic solution for the interaction between circularly symmetric inclusions.
  • Analysis of the forces acting on non-circularly symmetric inclusions.

Related Experiment Videos

  • Mathematical modeling of membrane-protein interactions.

    • Main Results:

    • Identified an exact analytic solution for repulsive interactions between similar, circularly symmetric inclusions on fluid membranes with finite tension (gamma) and bending rigidity (kappa).
    • The repulsive force extends over length scales of approximately sqrt(kappa/gamma), contrasting with attraction on tensionless membranes.
    • A small, algebraically long-ranged attractive force was found for non-circularly symmetric inclusions.

    Conclusions:

    • Finite membrane tension induces repulsive forces between certain membrane inclusions, a key factor in membrane remodeling.
    • The findings provide a physical basis for understanding protein-induced membrane deformations, relevant to caveolae and other cellular structures.
    • This model offers insights into the mechanics of membrane-associated biological processes.