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Related Experiment Videos

Deodorants: an experimental provocation study with hydroxycitronellal.

C Svedman1, M Bruze, J D Johansen

  • 1Department of Occupational and Environmental Dermatology, University Hospital, 205 02 Malmö, Sweden. cecilia.svedman@skane.se

Contact Dermatitis
|June 6, 2003
PubMed
Summary
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Hydroxycitronellal in deodorants can cause axillary dermatitis in individuals allergic to this fragrance ingredient. This study confirms hydroxycitronellal

Area of Science:

  • Dermatology
  • Allergology
  • Cosmetic Science

Background:

  • Axillary dermatitis is frequently linked to fragrance contact allergies.
  • Deodorants are often suspected as the cause of fragrance-induced dermatitis.
  • Cinnamic aldehyde (cinnamal) in deodorants is a known trigger for axillary dermatitis.

Purpose of the Study:

  • To investigate the role of hydroxycitronellal in deodorants causing axillary dermatitis.
  • To assess the reaction to hydroxycitronellal in individuals with and without known allergy to it.

Main Methods:

  • Patch tests with hydroxycitronellal solutions and deodorants.
  • Repeated Open Application Tests (ROAT) using deodorants with varying hydroxycitronellal concentrations.
  • Study involved 14 dermatitis patients, 7 with and 7 without hydroxycitronellal allergy.

Related Experiment Videos

Main Results:

  • Positive ROAT reactions occurred exclusively in patients allergic to hydroxycitronellal.
  • Reactions were localized to the axilla where hydroxycitronellal-containing deodorants were applied.
  • Hydroxycitronellal in deodorants (0.032-0.32%) can induce axillary dermatitis within weeks in sensitive individuals.

Conclusions:

  • Hydroxycitronellal is a significant allergen in deodorants contributing to axillary dermatitis.
  • Individuals with hydroxycitronellal hypersensitivity should avoid deodorants containing this ingredient.