Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The enteric nervous system II: gastrointestinal functions.

Mark Berner Hansen1

  • 1Department of Gastrointestinal Surgery K, H:S Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark. mbh@dadlnet.dk

Pharmacology & Toxicology
|June 6, 2003
PubMed
Summary

The enteric nervous system (ENS) regulates gastrointestinal functions like motility and secretions. Targeting ENS pathways offers therapeutic potential for various gut disorders, including constipation and intestinal angina.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrointestinal Transit Time Assessed Using a CT-Based Radiopaque Marker Method in Patients With Acute Pancreatitis During Methylnaltrexone Treatment.

Neurogastroenterology and motility·2025
Same author

No Effect of Methylnaltrexone on Acute Pancreatitis Severity: A Multicenter Randomized Controlled Trial.

The American journal of gastroenterology·2024
Same author

Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial.

Trials·2021
Same author

Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?

International journal of molecular sciences·2020
Same author

Characterisation of the fibroinflammatory process involved in progression from acute to chronic pancreatitis: study protocol for a multicentre, prospective cohort study.

BMJ open·2019
Same author

Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia.

BMC cancer·2019

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Physiology

Background:

  • The enteric nervous system (ENS) is a complex neural network within the gastrointestinal tract.
  • It plays a crucial role in regulating numerous physiological and pathophysiological processes.
  • This review focuses on the ENS's involvement in gastrointestinal functions.

Purpose of the Study:

  • To describe the role of the ENS in gastrointestinal functions including motility, secretions, blood flow, and immune responses.
  • To address the functional importance of the ENS in food intake, gallbladder, and pancreas.
  • To highlight therapeutic opportunities for ENS-related gastrointestinal diseases.

Main Methods:

  • Literature review of the ENS's role in gastrointestinal physiology and pathophysiology.

Related Experiment Videos

  • Discussion of specific gastrointestinal functions regulated by the ENS.
  • Analysis of neuroactive pharmacological agents for treating ENS-related disorders.

    • Main Results:

    • The ENS is integral to gastrointestinal motility, exocrine/endocrine secretions, blood flow, and immune processes.
    • ENS dysfunction is implicated in conditions such as dysmotility, diarrhea, constipation, and intestinal ischemia.
    • Specific ENS pathways are relevant to gallbladder and pancreatic functions.

    Conclusions:

    • The ENS is a critical regulator of gastrointestinal health and disease.
    • Neuroactive pharmacological agents targeting ENS pathways show promise for treating various gastrointestinal disorders.
    • Further research into ENS modulation could lead to novel therapeutic strategies.