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Related Experiment Videos

Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.

N Hishikawa1, Y Hashizume, N Ujihira

  • 1Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Neuropathology and Applied Neurobiology
|June 6, 2003
PubMed
Summary

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Alpha-synuclein accumulates in specific brain regions in diffuse neurofibrillary tangles with calcification (DNTC). This finding suggests alpha-synuclein accumulation is a pathological hallmark of DNTC, alongside tau pathology.

Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases

Background:

  • Alpha-synuclein is a key component of Lewy bodies in Parkinson's disease and related disorders.
  • Alpha-synuclein inclusions can co-localize with tau pathology in some neurodegenerative conditions.
  • Previous studies have not reported alpha-synuclein-positive structures in diffuse neurofibrillary tangles with calcification (DNTC).

Purpose of the Study:

  • To investigate the distribution of alpha-synuclein-positive structures in two cases of diffuse neurofibrillary tangles with calcification (DNTC).

Main Methods:

  • Investigated two cases of DNTC using alpha-synuclein immunohistochemistry.
  • Examined brain tissue for the presence and location of alpha-synuclein-positive inclusions and neurites.

Main Results:

Related Experiment Videos

  • Alpha-synuclein-positive intracytoplasmic inclusions and neurites were identified in specific brain regions of DNTC cases, including the temporal lobe, amygdala, parahippocampus, entorhinal cortex, and insula.
  • These alpha-synuclein deposits were concentrated in areas most affected by neurofibrillary tangles.
  • Alpha-synuclein-positive structures were rare or absent in other cortical and brainstem regions, differing from patterns seen in Parkinson's disease or dementia with Lewy bodies.

Conclusions:

  • The distinct accumulation pattern of alpha-synuclein in DNTC suggests it is a pathological feature of this condition.
  • Diffuse neurofibrillary tangles with calcification (DNTC) is associated with the co-accumulation of both tau and alpha-synuclein proteins.