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The inherited thrombophilias: genetics, epidemiology, and laboratory evaluation
Glenn S Buchanan1, George M Rodgers, D Ware Branch
1Department of Internal Medicine, University of Utah Health Sciences Center, 30 North 1900 East Medical Drive, Salt Lake City, UT 84132, USA.
Abstract:
It is now possible to identify a predisposing thrombophilic condition for venous thrombosis in well over half of the cases. Certain thrombophilia diagnoses have a major impact on anticoagulant therapy, and hence it is incumbent upon physicians to understand how to diagnose and manage these conditions. This chapter covers the genetics and epidemiology of the inherited thrombophilias and provides a useful, common-sense approach to the laboratory evaluation of a patient with venous thrombosis.