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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Acquired thrombophilias and pregnancy
Manjiri Khare1, Catherine Nelson-Piercy
1University Hospitals of Leicester, Women's and Perinatal Services, Gwendolen Road, LE5 4PW, Leicester, UK.
Summary
Antiphospholipid syndrome (APS) in pregnancy increases clotting risks. Current management with heparin and aspirin improves live birth rates to over 70% in affected pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Immunology
Background:
- Acquired thrombophilias are hypercoagulable states with increased risks during pregnancy.
- Antiphospholipid syndrome (APS) is a leading cause of acquired thrombophilia in pregnancy, linked to obstetric complications.
- Recent studies have clarified the pathogenesis of APS.
Purpose of the Study:
- To review the diagnosis and management of Antiphospholipid Syndrome (APS) in pregnancy.
- To highlight the importance of accurate diagnosis and current treatment strategies for APS in obstetric patients.
Main Methods:
- Review of current literature on antiphospholipid syndrome (APS) in pregnancy.
- Analysis of diagnostic criteria and therapeutic approaches for APS.
- Evaluation of outcomes with current management strategies.
Main Results:
- Antiphospholipid syndrome (APS) diagnosis relies on detecting anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LA).
- Standardized laboratory methods and updated clinical criteria have improved APS diagnosis.
- Current management using low-molecular-weight heparin and aspirin achieves >70% live birth rate in APS pregnancies.
Conclusions:
- Accurate diagnosis of Antiphospholipid Syndrome (APS) is critical for appropriate management and counseling.
- A multidisciplinary approach is vital for managing pregnant women with APS.
- While evidence for some treatments is limited, current strategies significantly improve pregnancy outcomes.
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