Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin: clinical relevance.

Russel J Reiter1

  • 1Department of Cellular and Structural Biology, Mail Code 7762, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. reiter@uthscsa.edu

Best Practice & Research. Clinical Endocrinology & Metabolism
|June 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.

Journal of pineal research·2017
Same author

Melatonin Attenuates Potato Late Blight by Disrupting Cell Growth, Stress Tolerance, Fungicide Susceptibility and Homeostasis of Gene Expression in <i>Phytophthora infestans</i>.

Frontiers in plant science·2017
Same author

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress.

Life sciences·2017
Same author

Melatonin as a potential inhibitory agent in head and neck cancer.

Oncotarget·2017
Same author

Association of melatonin membrane receptor 1A/1B gene polymorphisms with the occurrence and metastasis of hepatocellular carcinoma.

Oncotarget·2017
Same author

Melatonin alleviates low PS I-limited carbon assimilation under elevated CO<sub>2</sub> and enhances the cold tolerance of offspring in chlorophyll b-deficient mutant wheat.

Journal of pineal research·2017
Same journal

Control of muscle mass and accretion.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Multiple endocrine neoplasia type 2: From molecular genetics to precision therapy.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Nutritional advice for patients with obesity and prediabetes.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Effects of prolonged physical training on skeletal muscle mass accrual throughout the life span.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Type 2 diabetes and obesity in South Asian patients with polyendocrine metabolic ovarian syndrome: The emerging role of metabolomics.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Stress and the interaction of the hypothalamic-pituitary-adrenal axis with other pituitary axes and its consequences on muscle mass.

Best practice & research. Clinical endocrinology & metabolism·2026
See all related articles

Melatonin synthesis and secretion are regulated by the light:dark cycle and biological clock. Light exposure disrupts this cycle, affecting melatonin

Area of Science:

  • Neuroendocrinology
  • Chronobiology
  • Biochemistry

Background:

  • The pineal gland synthesizes and secretes melatonin, a hormone crucial for regulating circadian rhythms.
  • Melatonin production is tightly controlled by the light:dark cycle and the suprachiasmatic nuclei (SCN), the body's biological clock.

Purpose of the Study:

  • To review the neural pathways connecting the retina and pineal gland.
  • To summarize the regulation of melatonin synthesis and secretion by the circadian system.
  • To explore the clinical implications and therapeutic potential of melatonin.

Main Methods:

  • Review of existing literature on pineal gland function, circadian rhythms, and melatonin.
  • Description of cellular mechanisms of melatonin synthesis and signaling.

Related Experiment Videos

  • Analysis of the impact of light exposure on melatonin production.

    • Main Results:

    • Neural connections between the retina and pineal gland are essential for light-mediated melatonin regulation.
    • Disruption of the circadian melatonin cycle by light misuse affects hormone levels.
    • Melatonin receptors and signal transduction pathways in peripheral organs are elucidated.
    • Melatonin exhibits antioxidant and free radical scavenging properties.

    Conclusions:

    • Melatonin plays a significant role in regulating the biological clock, influencing sleep, jet lag, immune function, and cancer.
    • Understanding melatonin's mechanisms offers potential therapeutic applications for various clinical conditions.
    • Melatonin's antioxidant properties add to its potential health benefits.