Related Experiment Video

Updated: Aug 12, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Immunotherapy and prostate cancer

Joseph M Kaminski1, James B Summers, Matthew B Ward

  • 1Department of Radiology, Medical College of Georgia, Augusta, GA 30912, USA.

Cancer Treatment Reviews
|June 6, 2003
PubMed

Insights

Prostate cancer immunotherapy shows promise but requires more research. Overcoming challenges like vector design and tumor evasion is crucial for effective treatment, especially for metastatic disease.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapeutics

Background:

  • Prostate cancer is a leading cause of cancer death in the US.
  • Current therapeutic options are limited, particularly for metastatic prostate cancer.
  • New treatment modalities are actively being investigated.

Purpose of the Study:

  • To explore the potential of immunotherapy as a viable treatment for prostate cancer.
  • To highlight the need for combination approaches in cancer therapy.
  • To identify existing obstacles in prostate cancer immunotherapy.

Main Methods:

  • Review of current therapeutic limitations in prostate cancer.
  • Exploration of novel therapeutic strategies including immunotherapy.
  • Identification of challenges in implementing immunotherapy.

Main Results:

  • Immunotherapy is a feasible and promising therapeutic modality for prostate cancer.
  • A combination approach is likely necessary for treating most malignancies.
  • Significant obstacles remain in immunotherapy research and application.

Conclusions:

  • Further research in basic immunology is essential for advancing prostate cancer immunotherapy.
  • Addressing challenges such as vector design, tumoricidal specificity, and tumor evasion is critical.
  • Realizing the full therapeutic benefit of immunotherapy requires overcoming these obstacles.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...