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Related Experiment Videos

Calcium signalling in lymphocytes.

Monte M Winslow1, Joel R Neilson, Gerald R Crabtree

  • 1Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA. mwinslow@stanford.edu

Current Opinion in Immunology
|June 6, 2003
PubMed
Summary
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Calcium ion (Ca(2+)) signaling is crucial for B and T lymphocyte development and activation. Recent research clarifies the initiation of this pathway, including store-operated calcium entry and the CRAC channel, plus Ca(2+)-regulated genes and calcineurin in T cells.

Area of Science:

  • Immunology and Cell Biology
  • Molecular and Cellular Signaling

Background:

  • Intracellular calcium ion concentration ([Ca(2+)](i)) modulation is a fundamental signaling mechanism across biological systems.
  • B and T lymphocytes utilize Ca(2+) signaling for critical developmental and activation processes.

Purpose of the Study:

  • To elucidate the initiation mechanisms of Ca(2+) signaling in lymphocytes.
  • To identify the molecular components involved in calcium store-operated entry, including the CRAC channel.
  • To characterize Ca(2+)-regulated genes and calcineurin in T lymphocytes.

Main Methods:

  • Review of recent data on Ca(2+) signaling pathways.
  • Analysis of gene profiling studies in T lymphocytes.

Main Results:

Related Experiment Videos

  • New insights into the interplay between intracellular Ca(2+) store release and extracellular Ca(2+) influx.
  • Identification of key molecular players in the calcium release-activated calcium (CRAC) channel.
  • Discovery of genes regulated by [Ca(2+)](i) and the calcineurin phosphatase in T cells.

Conclusions:

  • Recent advancements have significantly improved our understanding of lymphocyte Ca(2+) signaling.
  • The molecular identity and function of the CRAC channel are becoming clearer.
  • Ca(2+) signaling pathways are intricately linked to gene expression and phosphatase activity in lymphocytes.