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Heterogeneity of CD4(+) and CD8(+) T cells

David L Woodland1, Richard W Dutton

  • 1Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA. dwoodland@trudeauinstitute.org

Current Opinion in Immunology
|June 6, 2003
PubMed

There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized. More recently it has become apparent that T-cell populations display additional diversity in terms of phenotype, anatomical distribution and effector function.

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