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Migration and T-lymphocyte effector function

Linda M Bradley1

  • 1Division of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA. lbradley@skcc.org

Current Opinion in Immunology
|June 6, 2003
PubMed

The development of immunity depends upon the capacity of responding T cells to become mobilized from lymphoid tissues where they are primed to sites of antigen exposure, wherever they occur in the body. Activation-induced alterations in the ability of T cells to migrate signify a fundamental change in biological function. Considerable attention is now focused on identifying mechanisms that regulate the migration and persistence of T cells that disseminate to non-lymphoid compartments as effector cells, and those that are retained in the lymphoid compartment. There are many unanswered questions about the developmental relationships and roles in protective immunity of antigen-experienced T cells that partition in different tissues.

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