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Updated: Aug 14, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Modifier genes and protective alleles in humans and mice
1Department of Genetics and Center for Computational Genomics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA. jhn4@po.cwru.edu
Abstract:
Interest in modifier genes is growing rapidly because of their ability to modulate the phenotype of individuals with monogenic and multigenic traits and diseases. A neglected class of modifiers is protective alleles that can suppress disease in otherwise susceptible individuals. Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems.
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