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ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle
Lori L Tortorella1, Connie B Lin, Paul F Pilch
1Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Room K404, Boston, MA 02118, USA.
Abstract:
Rat ERK6, also known as SAPK3 and p38gamma, exhibits a distinct pattern of expression during muscle development in vitro and in vivo. Levels of mRNA transcript and protein abundance for ERK6 are increased during the differentiation of 2 rodent myoblast cell lines in culture. This is in contrast to the expression of other MAP kinase family members, namely p42/p44 MAPK and p38 MAPK, whose expression does not change during myogenesis. Similar results are observed in vivo where ERK6 mRNA levels increase with post-natal development in rat hindlimb mixed muscle samples. These results delineate a distinct pattern of ERK6 expression in mature skeletal muscle cells and suggest a specific role for ERK6 in muscle development or muscle function.