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Updated: Sep 25, 2026

An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis
Published on: August 6, 2020
Choroidal neovascular membrane associated with optic nerve coloboma in a patient with CHARGE association
Medhat F Guirgis1, Gregg T Lueder
1Department of Ophthalmology, St. Louis, Missouri 63110, USA.
Purpose:
To report a patient with CHARGE association (coloboma, heart disease, choanal atresia, growth retardation, genital hypoplasia, and ear abnormalities) who developed a choroidal neovascular membrane in association with an optic nerve coloboma.
Design:
Interventional/observational case report.
Method:
A 21-month-old boy with CHARGE association developed a grayish choroidal neovascular membrane associated with lipid exudation, subretinal fluid, and retinal hemorrhage at the temporal edge of his right optic nerve coloboma.
Results:
The patient underwent transpupillary diode laser of the choroidal neovascular membrane. Five months later, it and the serous retinal detachment had resolved.
Conclusions:
Patients with CHARGE association may develop choroidal neovascular membrane with serous retinal detachments in association with optic nerve colobomas. These neovascular membranes may be treated successfully with transpupillary diode laser.
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