Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraoperative dynamic dose optimization in permanent prostate implants.

Eva K Lee1, Marco Zaider

  • 1Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA. evakylee@isye.gatech.edu

International Journal of Radiation Oncology, Biology, Physics
|June 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data-Driven Evidence-Based Patient-Centered Optimal Initiation Time for Dialysis Treatment.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Data-Driven Approach to Design an Efficient Mass Vaccination and Public Health Monitoring Informatics Platform.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

AAPM Task Group Report 267: A joint AAPM GEC-ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy.

Medical physics·2024
Same author

Temporal and spatial analysis of over 7,000 measles cases outbreak from 2018 to 2019 in the Brazilian Amazon.

Einstein (Sao Paulo, Brazil)·2024
Same author

New PK/PD model directly links diabetes drug dose to blood glucose level for personalized care.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2023
Same author

Analyzing Strategies for Containing Avian Influenza.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2023
Same journal

Local sinonasal and regional nodal effects of lymph node irradiation in a pilot study of dogs with naturally occurring sinonasal tumors.

International journal of radiation oncology, biology, physics·2026
Same journal

Cross-Institutional Validation of a novel LLM-Based Cardiac Event Extraction framework from Electronic Health Records.

International journal of radiation oncology, biology, physics·2026
Same journal

Cardiac Substructure Dosimetry and Major Adverse Cardiac Events After Breast Radiotherapy: A 12-Year Cohort Study with NTCP Modeling.

International journal of radiation oncology, biology, physics·2026
Same journal

Predictors of Medical Debt Sent to Collections after Radiotherapy.

International journal of radiation oncology, biology, physics·2026
Same journal

External Beam Radiotherapy Primes PDL1-Targeted Radionuclide Therapy in Preclinical Colorectal Cancer Model.

International journal of radiation oncology, biology, physics·2026
Same journal

Radiobiological characterization of 60 keV quasi-monoenergetic convergent photons.

International journal of radiation oncology, biology, physics·2026
See all related articles

Intraoperative dynamic dose optimization (IDDO) improves prostate cancer treatment by real-time plan adjustments for seed placement accuracy. This method enhances dose conformity and reduces radiation to surrounding tissues, potentially lowering morbidity.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Image-Guided Therapy

Background:

  • Permanent prostate brachytherapy offers high dose conformity.
  • Inaccuracies in seed placement lead to dose distribution variability.
  • Real-time plan adjustment is needed to account for actual seed positions.

Purpose of the Study:

  • To present and assess an algorithm for intraoperative dynamic dose optimization (IDDO).
  • To evaluate the impact of reoptimization frequency on treatment outcomes.
  • To improve dose coverage and conformity in permanent prostate implants.

Main Methods:

  • IDDO involves identifying seed coordinates, projecting images, and reoptimizing the treatment plan.
  • The study analyzed reoptimizing 2, 3, and 4 times during implantation.

Related Experiment Videos

  • Fifteen patient cases were used, with strict dose constraints for the urethra and rectum.

    • Main Results:

    • The initial optimized plan achieved 93% dose coverage and a conformity index of 1.32.
    • IDDO plans achieved 100% postimplant coverage with a conformity index of 1.16.
    • IDDO significantly reduced radiation dose to the urethra and rectum compared to the initial plan.

    Conclusions:

    • Dynamic reoptimization during brachytherapy accounts for actual seed positions and gland changes.
    • The IDDO method improves dosimetry, ensuring complete coverage and good conformity.
    • IDDO shows potential for reducing morbidity to the urethra and rectum through optimized radiation delivery.