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Synthesis and biological evaluation of novel turn-modified gramicidin S analogues
Gijsbert M Grotenbreg1, Emile Spalburg, Albert J de Neeling
1Leiden Institute of Chemistry, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands.
Bioorganic & Medicinal Chemistry
|June 6, 2003
Abstract:
The synthesis of novel gramicidin S analogues having additional functionalities in the turn region by employing a biomimetic approach is described. The preservation of beta-sheet character in all analogues was established by NMR and the biological activity was evaluated.
