Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alcohol hypoglycemia: hormonal changes.

D Andreani, G Tamburrano, M Javicoli

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of trans-sphenoidal surgery in pituitary GH-secreting micro- and macroadenomas: a comparison between microsurgical and endoscopic approach.

    Journal of neurosurgical sciences·2015
    Same author

    TSH receptor extracellular region mutations in thyroid functioning nodules: further evidence for the functional role of this region in the receptor activation.

    Endocrine·2011
    Same author

    [Efficacy of external conventional radiotherapy in short and long term control of acromegaly; a comparison with stereotactic irradiation].

    La Clinica terapeutica·2009
    Same author

    Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in somatostatin analogue-naive patients with acromegaly.

    Journal of endocrinological investigation·2009
    Same author

    Efficacy of a slow-release formulation of lanreotide (Autogel) 120 mg) in patients with acromegaly previously treated with octreotide long acting release (LAR): an open, multicentre longitudinal study.

    Clinical endocrinology·2007
    Same author

    Clinical characterization of familial isolated pituitary adenomas.

    The Journal of clinical endocrinology and metabolism·2006
    Same journal

    Inflammatory Profile of Lipedema: A Comparative Evaluation with Obese and Normal-weight Women.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Comparative Effects of Experimental Diabetes Mellitus and Glucocorticoid-Induced Hypercortisolemia on Pancreatic and Adrenal Endocrine Architecture: A Pathological Study in Rats.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Psychiatric Symptoms in Women with Mild Autonomous Cortisol Secretion Versus Non-Functioning Adrenal Adenomas: A Cross-Sectional Study.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Antisemitism as a Chronic Cardiometabolic, Endocrine, and Glutamatergic Stressor Requiring Psychometric Monitoring.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Severe Acute Respiratory Syndrome Coronavirus-2 Infection and New Changes in Thyroid Function Parameters during Hospitalization and Follow-up.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Maternal Serum Epidermal Growth Factor Levels at 37 Weeks of Gestation in Late-Term Pregnancies.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    See all related articles

    Alcohol infusion affects hormonal balance, potentially leading to hypoglycemia by depleting glycogen stores. Alcohol withdrawal can restore normal pituitary function in chronic alcoholics.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Neuroscience

    Background:

    • Alcohol consumption significantly impacts metabolic and hormonal regulation.
    • Fasting exacerbates alcohol's effects on glucose and hormone levels.
    • Understanding these interactions is crucial for managing alcohol-related health issues.

    Purpose of the Study:

    • To investigate the acute effects of alcohol infusion on hormonal (insulin, glucagon, cortisol, growth hormone), glucose, and free fatty acid (FFA) levels in fasted subjects.
    • To compare the pituitary and insular responses to alcohol versus saline infusions.
    • To assess the impact of alcohol withdrawal on hormonal responses in a chronic alcoholic patient.

    Main Methods:

    • Infusion of alcohol and saline in healthy young adults after 12 and 36 hours of fasting.

    Related Experiment Videos

  • Performance of an arginine stimulation test post-infusion to assess hormonal release.
  • Case study of a chronic alcoholic with hypoglycemia, monitored before and after alcohol withdrawal.

    • Main Results:

    • Alcohol infusion, especially after prolonged fasting, can lead to hypoglycemia by depleting glycogen stores.
    • Elevated levels of FFA, cortisol, and glucagon were observed during alcohol infusion, indicating an adrenergic response.
    • Growth hormone response to arginine stimulation was diminished after alcohol compared to saline.
    • A chronic alcoholic patient showed impaired pituitary growth hormone response, which normalized after alcohol withdrawal.

    Conclusions:

    • Alcohol may prime islet alpha and beta cells, but hypoglycemia occurs when substrate (glycogen) is deficient.
    • Alcohol's effects on hormonal balance and glucose metabolism are significant, particularly under fasting conditions.
    • Pituitary function, specifically growth hormone release, can be impaired by chronic alcohol use but may recover after cessation.