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Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor
R Lalonde1, T L Lewis, C Strazielle
1Faculté de Médecine et de Pharmacie, Université de Rouen, 22 boulevard Gambetta, INSERM EMI 9906, IFRMP 23, Bâtiment de Recherche, Salle 1D18, 76183 Rouen Cedex, France. robert.lalonde@umontreal.ca
Abstract:
The functional consequences of the betaAPP transgene with the Swedish mutation in mice were assessed in tests of exploratory activity and motor coordination. The betaAPP(695)SWE (Tg2576) transgenic mice are characterized by Abeta plaque formation in the neocortex and hippocampus. By comparison to non-transgenic mice controlled for age and gender, 17-month-old betaAPP(695)SWE transgenic mice displayed impaired spontaneous alternation, increased activity levels in the peripheral part of the open-field, and reduced anxiety in the elevated plus-maze. These results are similar to the loss of inhibitory control observed in some patients with Alzheimer's disease. These measures may be added to cognitive dysfunctions as testing ground for Abeta vaccination and other attempts at experimental therapies.