Related Experiment Video
Updated: Sep 25, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Synthetic urokinase inhibitors as potential antitumor drugs
1Curacyte Chemistry GmbH, Winzerlaer Strasse 2a, 07745 Jena, Germany. torsten.steinmetzer@curacyte.com
Abstract:
Urokinase-mediated plasminogen activation is involved in many normal physiological processes, including tissue remodeling, embryogenesis, wound healing and clot lysis. In addition, elevated levels of urokinase, the urokinase receptor uPA-R and its endogenous inhibitor plasminogen activator inhibitor (PAI-1), in combination with plasmin, play an important role in the pathogenesis of malignancy through its ability to mediate tumor cell growth, invasion and metastatic dissemination. The inhibition of urokinase with synthetic inhibitors is a new concept for a specific cancer therapy. This review examines synthetic urokinase inhibitors described during the last two years.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Antiviral Nucleoside Inhibitors
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...