[Natural substances as chemoprotective agents]

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K Lunerová1, D Veselá, R Kubínová

  • 1Ustav prírodních léciv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno. kristkovak@vfu.cz

Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
|June 7, 2003
PubMed

Insights

Natural compounds can prevent cancer and support chemotherapy by modulating xenobiotic detoxification enzymes and antioxidant activity. These agents offer potential in combating environmental carcinogens and mutagens.

Area of Science:

  • Pharmacology and Toxicology
  • Environmental Health
  • Natural Product Chemistry

Context:

  • Investigating xenobiotic metabolism and its role in disease development.
  • Identifying environmental factors (procancerogens, pro-mutagens) contributing to health disorders.
  • Focus on compounds influencing xenobiotic detoxification pathways and antioxidant defense.

Purpose:

  • To review natural compounds that modulate xenobiotic detoxification.
  • To explore the potential of these compounds as preventive agents against diseases.
  • To assess their utility as supportive therapies in chemotherapy.

Summary:

  • This review highlights natural compounds with the ability to modulate Phase I and Phase II xenobiotic detoxification enzymes.
  • It discusses compounds possessing antioxidant properties that can counteract environmental toxins.
  • Natural products are presented for their potential to prevent diseases linked to xenobiotic exposure and aid cancer treatment.

Impact:

  • Provides insights into natural preventive agents against cancer and other disorders.
  • Suggests natural compounds as supportive pharmaceuticals in chemotherapy.
  • Offers a basis for developing novel therapeutic strategies targeting xenobiotic metabolism.

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