[Cipramil treatment of neurotic depression]

Thirty one patients, aged 23-48 years, with ICD-10 diagnosis of psychogenic neurotic depression (F32.0 and F32.1), were studied. According to antidepressants used, the patients were divided into 2 groups, of which the test one included 19 patients treated by cipramil (20-40 mg/day) and the comparative one consisted of 12 patients treated with amitriptilin (25-50 mg/day). The treatment duration was 28 days. The patient's state was evaluated, using clinical approach and instrumental methods, i.e. Hamilton depression scale, before treatment and on 14th and 28th days. After cipramil treatment, 14 patients out of 19 exhibited an improvement, with 5 revealing neurotic symptoms compensation. However, 5 patients proved to be resistant to the medication. In amitriptilin treatment, complete depression reduction was found only in 1 patient, with pronounced improvement being shown in 8 out of 12 patients. No changes in the patient's state were revealed for 3 cases. Cipramil treatment was not accompanied with any side effects.