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Total artificial heart: destination therapy.

Louis E Samuels1, Robert Dowling

  • 1Hahnemann University Hospital, Broad & Vine Streets, Philadelphia, PA 19102-1192, USA. samuelsle@aol.com

Cardiology Clinics
|June 7, 2003
PubMed
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The AbioCor artificial heart offers permanent replacement for end-stage heart failure patients ineligible for transplants. Early trials show success, with one patient discharged home, demonstrating its potential for critically ill individuals.

Area of Science:

  • Cardiovascular Engineering
  • Medical Devices
  • Artificial Organs

Background:

  • The AbioCor is a unique artificial heart designed for permanent replacement in patients unsuitable for heart transplantation.
  • The CardioWest artificial heart, while also designed for permanent use, has proven effective as a temporary bridge-to-transplant solution.

Purpose of the Study:

  • To evaluate the feasibility and success of the AbioCor artificial heart in patients with end-stage heart failure.
  • To compare the application and patient profiles for the AbioCor and CardioWest devices.

Main Methods:

  • Clinical trial implantation of the AbioCor device in a cohort of critically ill patients.
  • Assessment of device performance, including the Total Electromechanical Tethering (TET) system.
  • Analysis of patient outcomes and selection criteria for both AbioCor and CardioWest.

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Main Results:

  • The AbioCor trial has shown initial success in four out of seven implanted patients.
  • A significant milestone was achieved with a patient being discharged home on the AbioCor.
  • The TET system demonstrated high efficacy in the study population.

Conclusions:

  • The AbioCor demonstrates potential as a permanent solution for non-transplant candidates with biventricular failure and limited survival.
  • CardioWest shows promise as a bridging device, particularly for cardiomyopathy patients awaiting transplantation.
  • Careful patient selection is crucial for optimizing outcomes with both artificial heart devices.