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HeartPatch implanted direct cardiac compression: effect on coronary flow and flow patterns in acute heart failure
Yifei Huang1, Gabrielle Gallagher, Serguei Plekhanov
1Cardiac Technology Centre, Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 7, 2003
Summary
Direct cardiac compression (DCC) with the HeartPatch device maintained coronary artery blood flow in sheep with acute heart failure. This novel device shows promise for supporting myocardial perfusion during cardiac distress.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
Background:
- Acute heart failure (HF) significantly impairs cardiac output and coronary circulation.
- The impact of direct cardiac compression (DCC) devices on myocardial perfusion in HF is not well understood.
Purpose of the Study:
- To investigate the effect of the HeartPatch DCC device on coronary artery blood flow (CABF) and its patterns in a sheep model of acute HF.
Main Methods:
- Ten sheep underwent implantation of HeartPatch devices on ventricular free walls.
- Acute HF was induced using esmolol, leading to reduced cardiac output and CABF.
- DCC device activation effects on CABF, flow velocities, and diastolic fraction were analyzed.
Main Results:
- DCC assist did not alter total antegrade CABF despite inducing significant changes in flow patterns.
- Peak antegrade and retrograde flow velocities increased substantially with DCC.
- The proportion of diastolic flow increased significantly, indicating altered coronary flow dynamics.
Conclusions:
- The HeartPatch DCC device effectively supports coronary circulation in acute HF.
- Myocardial perfusion is not compromised by DCC, suggesting its potential therapeutic benefit.